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KMID : 1021220160070021031
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국제물리치료학회지
2016 Volume.7 No. 2 p.1031 ~ p.1036
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A Study on the Effects of Needle Electrode Electrical Stimulation on the Number of c-Fos Response Cells and c-Fos Expression in the Global Ischemic Rats
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Kim Sung-Won
Song Young-Wha
Lee Jung-Sook
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Abstract
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c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.
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KEYWORD
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Ischemia, Striatum, c-Fos, Needle electrode electrical stimulation
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